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ATA - Construction works on Arbër Highway running at high rates
TIRANA, July 18/ATA/-The Albania’s Prime Minister Edi Rama shared Thursday in the social media a video showing the construction site...
NNA - Le vice-Premier ministre Ghassan Hasbani de l'ONU: le respect des objectifs de développement durable contribue à attirer le financement international au Liban
ANI-Le vice-Premier ministre Ghassan Hasbani a présidé la délégation libanaise au forum politique de haut niveau ...
NNA - جنحة لبنان تسلمت شهادة IOSA رئيس مطار رفيق الحريري الدولي - بيروت فادي الحسن
وطنية - تسلمت شركة 'أجنحة لبنان' wings of Lebanon خلال مؤتمر صحافي في فندق "هيلتون" - سن الفيل، شهادة IATA Operational Safety Audit "IOSA" العالمية، من منظمة الاتحاد الدولي للنقل...
ATA - Vetting/ Chief Prosecutor at Vlora Judicial District Court dismissed
TIRANA, July 18/ATA/- The Independent Qualification Commission IQC dismissed Thursday from office the Chief Prosecutor at the Vlora Judicial District...
NNA - بطولة آسيا للشابات في كرة اليد
وطنية - تعقد اللجنة الفنية لبطولة آسيا الـ15 للشابات (تصفيات بطولة العالم - رومانيا 2020) في كرة اليد اجتماعا موسعا عند الساعة الرابعة من بعد ظهر الجمعة 19 تموز الحالي...
NNA - روجيه فغالي بطل المرحلة الرابعة لسباق السرعة
وطنية - أحرز السائق روجيه فغالي لقب الجولة الرابعة من بطولة لبنان لسباقات السرعة "سبيد تست" للعام الجاري والتي نظمها النادي اللبناني للسيارات والسياحة في "المزار موتور بارك" بكفردبيان بمشاركة...
ATA - Vetting/ Tirana Court Judge dismissed
TIRANA, July18 /ATA/-The Independent Qualification Commission IQC dismissed Thursday from office the Judge of the Tirana Court and a candidate...
NNA - افتتاح الدورة 35 لمهرجانات بيت الدين
وطنية - افتتحت مهرجانات بيت الدين لصيف عام 2019 بدورتها ال35، مساء اليوم، في احتفال ضخم أحياه كابريال يارد وياسمينة جنبلاط، وحضرته شخصيات وفاعليات ثقافية واجتماعية وسياسية وأهلية وإعلامية. ...
NNA - Launch of Directors Lab Mediterranean at the American University of Beirut (AUB)
NNA - Directors Lab Mediterranean, a sister Lab to Lincoln Center Theater Directors Lab in NYC founded by Anne Cattaneo...
CNA - وزيرا دفاع قبرص واليونان يناقشان الاستفزازات التركية غداً
وكالة الأنباء القبرصية - قبرص / نيقوسيا - مهى ميخائيل
يناقش وزيرا الدفاع في قبرص واليونان سافاس أنجيليدس ونيكوس باناجيوتوبولوس الاستفزازات التركية في المنطقة الاقتصادية الخالصة لقبرص والمياه الإقليمية، وذلك خلال...
CNA - وزيرا التعليم في قبرص وصربيا يناقشان تنفيذ مذكرة التفاهم
وكالة الأنباء القبرصية - قبرص / نيقوسيا - مهى ميخائيل
يجري وزير التعليم والعلوم والتنمية التكنولوجية الصربي ملادين سارزيفيتش زيارة إلى قبرص تستغرق يومين بدعوة من نظيره القبرصي كوستاس خامبياوريس، بهدف...
CNA - المتحدث الرسمي باسم الحكومة: الرئيس اناستاسياديس مستعد للقاء الزعيم القبرصي التركي
وكالة الأنباء القبرصية - قبرص / نيقوسيا - مهى ميخائيل
قال المتحدث الرسمي باسم الحكومة برودروموس برودرومو اليوم أن الرئيس نيكوس أناستاسياديس مستعد للقاء زعيم القبارصة الأتراك مصطفى أكينجي،...
Lusa - Business News - Angola: Parliament approves 14% VAT starting in October
Luanda, Jul. 18, 2019 (Lusa) – Angola’s parliament on Thursday approved amending the Value Added Tax (VAT) law, which is...
Lusa - Business News - Portugal: Government approves transfer of investment fund supervision to CMVM
Lisbon, Jul. 18, 2019 (Lusa) – Portugal’s government on Thursday approved a bill that transfers the supervision of investment fund...
Lusa - Business News - Cabo Verde: Economy grows again in second quarter
Praia, Jul.18,2019 (Lusa)-Cabo Verde's economy returned to growth in the second quarter, after a drop in the first three months...
Lusa - Business News - Portugal: Government to crack down on use of mobile phones while driving
Lisbon, Jul.18,2019 (Lusa)–Portugal’s government on Thursday said that it is to change the Highway Code to increase penalties for the...
Lusa - Business News - Mozambique: Domestic gas imports to increase
Maputo, Jul.18,2019 (Lusa)-Mozambique will increase domestic gas imports by 1,100 tonnes in the second half of this year, Imopetro, the...
Lusa - Business News - Portugal: Sines port terminal XXI expansion agreed
Lisbon, Jul. 18, 2019 (Lusa) – Portugal's government and Sines Port Authority reached an agreement on Thursday over expansion and...
Lusa - Business News - CORRECTION: Mozambique: Strong demand makes hydroelectric increase share sale
Correction of the percentages in paragraphs 1 and 6
Maputo, Jul. 18, 2019 (Lusa) – The percentage of the share capital...
Lusa - Business News - Mozambique: Airports handled 14,000t of cargo in 2018, against 40,000t capacity
Maputo, July 18, 2019 (Lusa) – Mozambique’s airports last year handled 26,000 tons of cargo less than their installed capacity...
Lusa - Business News - Portugal: InovCluster manages project to increase qualification of SMEs
Castelo Branco, Portugal, Jul. 18, 2019 (Lusa) – Portugal’s Association of the Agroindustrial Cluster of the Centre (InovCluster) is developing...
CNA - الرئيس أناستاسياديس يلتقي مع مساعد الأمين العام للأمم المتحدة لعمليات حفظ اسلام
وكالة الأنباء القبرصية - قبرص / نيقوسيا - مهى ميخائيل
يلتقي رئيس الجمهورية نيكوس أناستاسياديس مع مساعد الأمين العام للأمم المتحدة لعمليات حفظ السلام جان بيير لاكروا يوم الأربعاء 24 تموز...
Lusa - Business News - Portugal: Indebtedness of non-financial companies up €3.4B in May to €729.6B
Lisbon, July 18, 2019 (Lusa) – The indebtedness of non-financial companies in Portugal in May increased by €3.4 billion to...
Lusa - Business News - Mozambique: Strong demand prompts HCB to increase stake sold to investors to 4%
Maputo, July 18, 2019 (Lusa) – The percentage of the shares in Mozambique state hydroelectric power company HCB placed for...
Lusa - Business News - Portugal: Government prepares contingency plan for proposed truckers' strike
Lisbon, Jul. 18, 2019 (Lusa) - João Galamba, Portugal's secretary of state for energy said on Thursday that an "emergency...
Lusa - Business News - Mozambique: Strong demand makes hydroelectric double sale on stock exchange
Maputo, Jul. 18, 2019 (Lusa) – The percentage of the share capital of Mozambique’s hydroelectric HBC put on sale increased...
Lusa - Business News - Portugal: Algarve public awareness campaign to save water gets underway
Faro, Portugal, Jul 18, 2019 (Lusa) – The Algarve Water Company, Águas do Algarve, is starting a campaign to raise...
CNA - Amendments to foreclosure framework hamper banks’ efforts to reduce problem loans, Moody’s warns
CNA - ΝICOSIA - Moody’s rating agency warned on Thursday that the amendments approved by the Parliament of Cyprus to...
HINA - Croatia's Q1 survey unemployment rate at 7.6%
ZAGREB,July18(Hina)-Croatia's survey unemployment rate stood at 7.6% in the first quarter of 2019,decreasing by 2.7 percentage points from the same...
Lusa - Business News - Cabo Verde: PM to launch road work schemes on Santo Antao and Sao Vicente
Praia, Cabo Verde, Jul. 18, 2019 (Lusa) – On a visit to Santo Antao and Sao Vicente, Cabo Verde’s Prime...
Lusa - Business News - Portugal: State Street Corporation acquires qualified position in EDP utility
Redação, 17 jul 2019 (Lusa) – State Street Corporation acquired a qualified stake in power utility company EDP after reaching...
Lusa - Business News - Portugal: Final CGD report approved unanimously
Lisbon, Jul. 18, 2019 (Lusa) – The final report of the parliamentary committee of inquiry into state-owned Caixa Geral de...
Lusa - Business News - Portugal: PSI20 opens 0.48% down at 5,226.82 points
Lisbon, Jul. 18, 2019 (Lusa) – The Lisbon stock exchange opened in negative territory on Monday with the main benchmark...
Lusa - Business News - Portugal: Top headlines on Thursday
Lisbon, Jul. 18, 2019 (Lusa) – The possibility of Portugal’s finance minister Centeno being appointed the head of the IMF...
EFE - SPAIN MEDICINE - Scientists develop 'genetic bomb' that targets just the bad bacteria




By Noemí G. Gómez
Madrid, Apr 15 (EFE).- Antibiotics are the first line of defense when it comes to fighting infections, but they are not selective and so kill off bacteria indiscriminately. Now, a group of scientists has managed to develop a new kind of antibiotic that can be programmed to tackle only the bad bacteria.
This new antibiotic, whose makers have dubbed a "programmable genetic bomb," also counteracts the build up of resistance; a global problem that the World Health Organization considers will cause some 10 million deaths in 2050.
The drug, which has been tested on living things, has been outlined in Nature Biotechnology magazine by researchers from the Technical University of Madrid (UPM) and Paris' Pasteur Institute.
One of the main drawbacks of antibiotics is that they attack almost all the bacteria in the body indiscriminately, which means they also get rid of ones that are beneficial. This process has led to the creation of multi-resistant bacteria, the UPM said in a statement.
And so there is a need to conduct research into intelligent drugs, Alfonso Rodríguez-Patón, a professor at the department of artificial intelligence at the UPM who is involved in the process, told Efe.
"This research opens a new line in the design and development of custom-made antibiotics, that is, selective ones to attack only the bad bacteria and programmable because they can be designed to attack one type of bacteria or another," the researcher said.
In the same way that probiotics are being developed to regulate gut microbiota, "we have designed programmable 'sentinel bacteria' capable of detecting and killing only the dangerous bacteria without affecting the good bacteria," Rodríguez-Patón added.
And for that, the research team has created something called a "programmable genetic bomb": a protein that is toxic just to bad bacteria.
The toxin travels to the sentinel bacteria and is programmed to activate and kill off only the bad bacteria that it recognizes, whether it is virulent or resistant to antibiotics.
"We can explain it as if it were a grenade, that it's an explosive device with a ring. The grenade only goes off if you pull out the ring and our toxin only goes off if it encounters a bad or resistant bacteria," Rodríguez-Patón said.
"We have programmed sentinel bacteria to prevent the genetic bombing of neighboring bacteria," Rodríguez-Patón added of the process, called "conjugation."
Bacteria have "hairs" that work like syringes, uniting sentinel bacteria with neighboring ones and antibiotics are transmitted via these hairs.
If the "genetic bomb" gets into a bad bacteria it will detect certain molecular signals, such as virulence or resistance to antibiotics, which will activate and kill the bacteria. If the antibiotic gets into a good bacteria, it will not react.
This mechanism of selective antibiotic activation can be programed to fight different resistant bacteria thanks to a molecule called intein, for which the Pasteur Institute has requested a patent.
The effectiveness of these antibiotics has been tested on living organisms, including zebra fish and crustaceans infected with the aquatic bacterium of cholera.
"We've succeeded in having our antibiotic get rid of the virulent and antibiotic-resistant cholera in infected zebra fish and that the rest of the bacteria present in the fish have not been affected and survive," the UPM researcher said.
This is significant, according to Rodríguez-Patón, as cholera affects over one million people every year and in serious cases can lead to death.
In order for these new antibiotics to become a reality, the next step is to test them on mice, Rodríguez-Patón said, adding that although it was too soon to be sure, they could be used to treat multi-resistant bacterial infections in human beings if they pass.
The development was possible thanks to engineers, physicians and microbiologists and is part of the European project Plaswires, headed by Rodríguez-Patón. EFE
ngg/sh/jt

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Agency : EFE

Date : 2019-04-16 09:34:44







 

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